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What Is Neopentyl Glycol?

Views: 276     Author: Vickey     Publish Time: 2023-06-12      Origin: Site


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What Is Neopentyl Glycol?

Neopentyl glycol is a colorless to white, hygroscopic, crystalline organic chemical compound (IUPAC name: 2,2-dimethylpropane-1,3-diol). The flammable, somewhat poisonous substance can be dangerous if consumed or absorbed through skin contact. It is known to irritate the skin and the eyes. It is used to create plasticizers, paints, lubricants, and polyesters. It improves the product's resistance to heat, light, and water when employed in the production of polyesters. Synthetic lubricating esters with lower oxidation or hydrolysis potential than natural esters can be created by esterifying reactions with fatty or carboxylic acids.


Neopentyl glycol has the chemical formula C5H12O2. It has a CAS of 126-30-7. Industrial-scale production of the crystalline material involves the aldol reaction between formaldehyde and isobutyraldehyde.As a result, hydroxypivaldehyde is produced as an intermediate, which may then be used to produce neopentyl glycol using either a Cannizzaro reaction with extra formaldehyde or a hydrogenation process utilizing palladium on carbon. It is utilized as a protective group for ketones, for instance, in the synthesis of gestodene, because of its propensity to produce cyclic derivatives (see Thorpe-Ingold Effect). The process also produces boronic acid esters, which are helpful in cross-coupling processes.Neopentyl glycol and 2,6-di-tert-butylphenol are combined to produce CGP-7930. A precursor of neopentyl glycol diglycidyl ether is neopentyl glycol. A Lewis acid catalyst is used to alkylate epichlorohydrin at the start of the process. The required ether is produced by dehydrochlorinating the resultant halohydrin with sodium hydroxide.


New pentadiol is extensively used, primarily in the production of unsaturated resin, free resin, polyurethane foam plasticizer, surfactant, insulating materials, printing ink, polymer inhibitors, synthetic aviation oil additives, etc. New pentadiol is a superb solvent that can be used to select the separation of aromatics and alkyl hydrocarbons; its ammonia baking paint has good light protection and doesn't yellow. Additionally, it can be utilized as a raw ingredient to make insecticides, stabilizers, and polymer inhibitors.


It has been noted that neopentyl glycol plastic crystals display a cooling effect known as a colossal barocaloric effect (CBCE), which is brought on by pressure-induced phase transitions. At room temperature, the measured entropy changes are 389 joules per kilogram per kelvin.This CBCE phenomenon is likely to be very useful in future solid-state refrigeration technologies.

Storagement management

When storing, keep the packaging intact. Avoid combined storage and keep food chemicals and oxidants isolated from each other. Facilities for lighting and ventilation that are explosion-proof are used. No use of mechanical devices or spark-prone tools The storage space must be outfitted with proper reception materials, leaking emergency treatment equipment, and ventilation in order to keep sunlight out of the open fire. Storage must be done between -50°C and -45°C.

Operation measures

Strengthen the ventilation when the operation is closed. Chemical safety goggles, anti-poison work attire, and rubber oil-resistant gloves are required for operators. Avoid smoking in the workplace and keep your distance from any fire or heat source.Utilize equipment and a ventilation system that are explosion-proof. Stop the leaking of steam into the air at the workplace. Keep your distance from the oxidant. When packing, care should be taken to prevent the buildup of static electricity, and a grounding device should be present. Lightly unload while handling to avoid damaging the package. equipped with a sufficient range and number of firefighting tools and leak emergency treatment tools.

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