Views: 284 Author: Vickey Publish Time: 2023-06-21 Origin: Site
The water-soluble polymer compound polyvinylpyrrolidone (PVP), also known as polyvidone or povidone, is created from the monomer N-vinylpyrrolidone and iodine. PVP can be chosen based on the desired application qualities and is offered in a variety of molecular weights and associated viscosities.
Povidone, commonly known as polyvinylpyrrolidone, or PVP, is a synthetic polymer used in the pharmaceutical industry as a medium for distributing and suspending medications. It may be used as an adhesive for transdermal systems, a binder for tablets and capsules, a film-forming agent for ophthalmic solutions, a flavoring agent for liquids and chewable tablets, and more.
Povidone is a white to slightly off-white powder with the chemical formula (C6H9NO)n.Pharmaceutical companies frequently utilize povidone formulations because of their capacity to dissolve in both water and oil-based solvents. Povidone's mean molecular weight is indicated by the k number. Higher K-value povidones are often not administered by injection due to their large molecular weights. Higher molecular weights inhibit renal elimination and cause the body to accumulate. The well-known disinfectant povidone-iodine is an illustration of a povidone composition.
A patent application for one of the acetylene chemistry derivatives, PVP, was made in 1939 by BASF chemist Walter Reppe. PVP has a wide range of uses in medical, pharmacy, cosmetics, and industrial production. It was first employed as a replacement for blood plasma.
Water and other polar solvents can dissolve PVP. It is soluble, for instance, in a variety of alcohols, including methanol and ethanol, as well as in more unusual solvents, such as the deep eutectic solvent produced by the combination of choline chloride and urea (Relin). It easily absorbs up to 40% of its weight in atmospheric water when dry, transforming into a light, flaky, hygroscopic powder. It forms films easily in solution and has excellent wetting characteristics. Because of this, it works well as a coating or coating additive.PVP and its oxidized hydrolyzate have luminous characteristics, according to 2014 research.
This chemical has received approval from the U.S. Food and Drug Administration (FDA) for a variety of applications, and it is generally accepted as safe (GRAS). For usage in oral, topical, and injectable formulations, PVP is included in the Inactive Ingredient Database.The use of PVP/povidone subcutaneously (applied under the skin) and instances in which the PVP came into contact with autologous serum (internal blood fluids) and mucosal membranes have both been linked to reported incidences of allergic responses. Povidone is frequently used in combination with other substances as well. Some of them, like iodine, are held responsible for allergic reactions. However, later tests on some people revealed no evidence of a chemical allergy. It's possible that the PVP, rather than the allergies linked to these other chemicals, is to blame.
There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
